Our ingredients

All our ingredients have been selected with the utmost care
to guarantee quality and effectiveness, whilst always respecting the environment.

a

Acerola is a plant commonly found in the Caribbean, its fruit is rich in Vitamin C. Vitamin C is important because it bolsters the natural immune defences, protecting our bodies against infections. It plays an essential role in many oxidative processes and in collagen and carnitine synthesis. It also promotes iron absorption.

Source(s):
Narayan M.S. et al. Antioxidant effect of anthocyanin on enzymatic and non-enzymatic lipid peroxidation. Prostaglandins Leukot. Essent. Fatty Acids 60, 1-4, 1999

Product(s):
IS3 / MIRABILUS IMMUNO PLUS

Aloe is a succulent plant with characteristically thick and fleshy leaves with small spikes running along their edges. The dry extract of this plant is a (200:1) concentrate of powdered leaf pulp, rich in vitamins, mineral salts and amino acids – a true phytocomplex. The wide variety of substances it contains is the foundation of the product’s health-enhancing properties, making it useful as an anti-inflammatory for the gastrointestinal mucosae, an immunostimulant – thanks to the presence of acemannan, as a detoxifier and more. Numerous clinical trials have been conducted on its topical use as a gel and its oral use in capsule form. The only warning concerns Aloin. A substance found in the outer part of the leaf, which has laxative and irritant properties on the colon. At a daily dose of 1 g or more, it can cause diarrhoea, abdominal pain and physical weakness. Given that the dry extract is sourced from the leaf pulp, it does not contain Aloin, making the product safe.

Source(s):
Assessment report on Aloe barbadensis Mill. and on Aloe (various species, mainly Aloe ferox Mill. and its hybrids), folii succus siccatus. EMA/HMPC/759585/2015

Product(s):
DS1 / TERSUS

Angelica is a biennial plant belonging to the Umbelliferae family. The powder obtained from the plant’s root is rich in polysaccharides that promote gastric cellular growth and decrease the production of hydrochloric acid – present in digestive gastric juices. In the case of gastric or duodenal ulcers, this makes it possible to rejuvenate the epithelium and encourages it to heal. The only warning applies to mothers-to-be, since it contains furanocoumarins and in cases of high dosage can cause uterine contractions.

Source(s):
Angelica Archangelica Linn. is an angel on earth for the treatment of diseases. ZA Bhat,  Dinesh Kumar,  MY Shah. Internation Journal of Nutrition, Pharmacology, Neurological disease. 36-50, 2011

Product(s):
DS1 / TERSUS
DETOXIFYING HERBAL TEA

The Annurca apple is a PGI apple variety coming from the Campania region of Italy, rich in polyphenols, in particular B-type procyanidins. It contains concentrations, 2 to 4 times higher than other apples. The apple’s therapeutic properties are concentrated in the dry fruit extract, making it very beneficial for people with high cholesterol. B-type procyanidins have a similar effect as statins but without their side effects. Some clinical trials have even highlighted they have the ability to programme cells in such a way as to eliminate cholesterol when it is too high, thus reducing inflammatory response – a mechanism similar to that of beta-cyclodextrins.

Source(s):
A Healthy Balance of Plasma Cholesterol by a Novel Annurca Apple-Based Nutraceutical Formulation:
Results of a Randomized Trial. Gian Carlo Tenore,Domenico Caruso,Giuseppe Buonomo Maria D’Avino Pietro Campiglia Luciana Marinelli, and Ettore Novellino. Med Food 20 (3) 2017, 288–300

Product(s):
CS1 / BERGACOL

Arnica is a herbaceous plant belonging to the Compositae family. It has characteristic yellowish-orange flowers, used in herbal medicine as a natural anti-inflammatory and for pain-relief. The sesquiterpenes found in the extract act on certain gene transcription factors that encourage cellular inflammation, thus reducing cytokine and macrophage production. It is beneficial in cases of traumatic muscle pain, rheumatism and haematoma – especially when used as a cream, gel or ointment. It is not taken orally because there is a risk of ingesting toxic substances.

Source(s):
Assessment report on Arnica montana flos. EMA/HMPC/198794/2012

Product(s):
MSS1 / ARNICA30

Astragalus is a plant belonging to the Fabaceae family. Its root is the medicinal part, made up mainly of polysaccharides – 70% of the extract, flavonoids and triterpene saponins (astragalosides). It has immune stimulant and anti-inflammatory properties due to its high percentage of polysaccharides. One of the ways astragalus stimulates the immune system is by regulating the lymphocyte families and restoring the body’s normal humoral immune functions.

Source(s):
Am J Chin Med. 2017;45(6):1157-1167. doi: 10.1142/S0192415X1750063X. Epub Zhongguo

Product(s):
IS3 / MIRABILUS IMMUNO PLUS

Ash tree is a plant belonging to the Oleaceae family, possessing remarkable medicinal properties. The dried leaf extract has diuretic, anti-inflammatory, antirheumatic and antiarthritic properties thanks to the presence of coumarins (fraxin, fraxetin, fraxinol, aesculetin) and flavonoids (quercetin, rutin, hydroxyframoside). They inhibit the production of endogenous inflammatory mediators like prostaglandins.

Source(s):
Assessment report on Fraxinus excelsior folium. EMA/HMPC/239269/2011

Product(s):
MSS1 / ARNICA30
MSS2 / ARTUUM

b

Bergamot orange is a citrus plant belonging to the Rutaceae family. The fruit is the part typically used in phytotherapeutics, due to its high polyphenol content – especially flavonoids. Helping to combat atherosclerosis thanks to their cholesterol lowering, antioxidant and anti-inflammatory properties. Its ability to lower triglycerides and “bad cholesterol” LDL levels and increase “good cholesterol” HDL levels is due to the structure of two flavonoids in particular, whose activity is similar to that of statins – cholesterol-lowering prescription drugs. They inhibit the action of a liver enzyme, HMG-CoA reductase, which is responsible for cholesterol production. Unlike statins, however, bergamot doesn’t cause muscle pain and therefore ideally suited as a safe alternative for cholesterol lowering therapy.

Source(s):
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies Mollace V1, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S, Muscoli C, Rotiroti D, Romeo F. Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4

Product(s):
CS1 / BERGACOL

Birch is a perennial belonging to the Betulaceae family. It is widely used in phytotherapeutics, thanks to its leaves and sap properties. Gemmotherapy extract obtained from birch sap contains two heterosides that can enzymatically be converted into methyl salicylate, a substance with analgesic and anti-inflammatory activities. Methyl salicylate works on the COX-2 enzyme, an important enzyme in the inflammatory cascade, inhibiting its action and thus significantly reducing pain and eliminating fluids that have accumulated in tissues. It is an excellent remedy in cases of rheumatoid arthritis or joint inflammation.

Source(s):
Assessment report on Betula pubescens. EMA/HMPC/573240/2014

Product(s):
MSS1 / ARNICA30
MSS2 / ARTUUM

Citrus aurantium is a tree belonging to the Rutaceae family. Its fruit is better known as the bitter orange. Synephrine is found in the fruits’ peel, a substance capable of acting on the receptors located on the surface of adipocytes, the cells that make up adipose tissue. Synephrine encourages the release of stored fats and promotes fat burning by increasing thermogenesis.

Source(s):
An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. Ipek Suntar, Haroon Khan, Seema Patel, Rita Celano, Luca Rastrelli. Oxid Med Cell Longev. 2018

Product(s):
M1 / SINE ADIPEM

Black cohosh belongs to the Ranunculaceae family. The dry extract obtained from its roots contains triterpene glycosides, alkaloids, tannins, cimicifugin and flavonoids giving the plant anti-inflammatory properties and aiding the rebalance of the female hormonal system. Scientific studies have shown using black cohosh to treat menopause problems has improved neuro-vegetative symptoms such as hot flashes, sweats, headaches, dizziness, heart palpitations, ringing in the ears, anxiety, irritability, sleep disorders and depression. Phytoestrogens in black cohosh are able to bind to the serotonin receptors in the hypothalamus – a nucleus of nerve cells located in the lower part of the brain, having a similar effect produced by the neurotransmitter serotonin. Beneficial in the treatment of menopausal and premenstrual syndrome, dysmenorrhea (menstrual pain) and oligomenorrhea (infrequent or very light menstruation).

Source(s):
Assessment report on Cimicifuga Racemosa Rhizoma EMA/HMPC/48744/2017

Product(s):
RPS1 / ADHUC

Bromelain is a proteolytic enzyme contained in pineapple – its concentration is measured in proteolytic units. Bromelain, is used medicinally as an anti-inflammatory and antioedemic. Bromelain is safer than other anti-inflammatories due to differences in the action mechanism. NSAIDs inhibit cyclooxygenase, blocking prostaglandin synthesis, while bromelain “diverts” the synthesis, increasing the production of anti-inflammatory prostaglandin to the detriment of pro-inflammatory prostaglandins, thus preventing gastrointestinal damage typically caused by NSAIDs.

Source(s):
Properties and Therapeutic Application of Bromelain: A Review. Rajendra PavanSapna JainShraddha, and  Ajay Kumar. Biotechnol Res Int. 2012; 2012: 976203

Product(s):
RPS3 / PROSTAHELP

See also: SULFORAPHANE.

Broccoli is a plant belonging to the Brassicaceae family. Rich in vitamins A, C and K, and Mineral salts such as potassium, iron, phosphorous, calcium and sulphur – responsible for its characteristic cooking smell. There is one substance in particular that is obtained from broccoli sprouts, sulforaphane, which has aroused great interest due to its high antioxidant activities, strong enough to protect every cell from any sort of oxidative or inflammatory damage. In fact, Sulforaphane activates a large number of enzymes that play a role in cellular redox reactions and at a genetic level – regulates endogenous detoxification mechanisms. For this reason, it has been studied in numerous clinical cases. In pulmonary diseases, Sulforaphane has been shown to increase the broncho-protective activities of other natural agents. In digestive diseases where there is a high degree of oxidative stress in the gastrointestinal mucosae, like infections caused by Helicobacter pylori or those caused by non-steroidal anti-inflammatories, Sulforaphane has been shown, both in vitro and in vivo, to have good antibacterial activity. Thus effective against Helicobacter pylori, as well as playing a cytoprotective role in cases of drug-induced gastritis.

Source(s):
Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress Akinori Yanaka. Division of Gastroenterology, Hitachi Medical Education and Research Center, Faculty of Medicine, University of Tsukuba, 2-1-1, Jonan-cho, Hitachi-shi, Ibaraki-ken, 317-0077, Japan Curr Pharm Des. 2017 Aug; 23(27): 4066–4075

Fahey, J. W., & Talalay, P. (1999). Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food Chem Toxicol, 37(9-10), 973-979<

Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways Robert H. Brown,Curt Reynolds, Allison Brooker, Paul Talalay, and Jed W. Fahey. Respir Res. 2015; 16(1): 106

Product(s):
DS2 / REFLUX HERBA
IS1 / ANTOXI PLUS
IS2 / ANTOXI PLUS FLUID
M1 / SINE ADIPEM
RS1 / SULFOSIN
RS3 / MIRABILUS VOX
RS4 / MIRABILUS PETTORALIS

c

Calamus is a plant native to Asia and has been used in traditional natural medicines by various cultures. Its beneficial properties are well-known to Native Americans, who have used it in sacred rituals. Principally, the plant’s roots are used. The phytotherapeutic constituents of calamus have antispasmodic properties, aid digestion and invigorate the body.

Source(s):
Annekatrin Puhle, Jürgen Trott-Tschepe, Birgit Möller. Heilpflanzen für die Gesundheit. Franckh-Kosmos Verlag 2013 

Product(s):
DETOXIFYING HERBAL TEA

California poppy grows mainly in California and Mexico. Its active constituents are mainly extracted from its aerial parts. It contains alkaloids that have a sedative effect on nerve cells. Consequently, California poppy has spasmolytic and anxiolytic effects, helping to alleviate insomnia and reduce stress.

Source(s):
https://www.actaplantarum.org/flora/flora_info.php?id=8454&pid=-1&p=2
Benzophenanthridine alkaloids isolated from Eschscholtzia californica cell suspension cultures interact with vasopressin (V1) receptors. Granger, Serradeil-le Gal C, Augereau JM, Gleye J. Planta Med. 1992 Feb;58(1):35-8.

Product(s):
RELAXING HERBAL TEA

Centella asiatica is a perennial herbaceous plant originating from Southeast Asia. Traditionally used to facilitate the healing of wounds – externally, on the skin or internally, on the mucous membranes. For this very reason, studies on treating gastric ulcers have been carried out. The plant stimulates cell proliferation as well as the synthesis of glycosaminoglycans, collagen and elastin, thus improving cell reconstruction.

Source(s):
Assessment report on Centella asiatica Urban Herba. EMA/HMPC/291177/2009 

Product(s):
DS2 / REFLUX HERBA

Chamomile is an annual herbaceous plant belonging to the Asteraceae family, traditionally used as a remedy for insomnia, gastric acidity and pain caused by poor digestion. Chamomile contains several polysaccharides and flavonoids, and is particularly rich in α-bisabolol and apigenin giving it its gastro-protective and anti-inflammatory properties. In vivo studies have highlighted its ability to reduce spasms in the stomach’s and digestive tube’s smooth muscle, and decrease oxidative damage caused to the digestive system by ethanol and medicines.

Source(s):
Assessment report on Matricaria recutita L., flos and Matricaria recutita L. aetheroleum/HMPC/55837/2011 

Product(s):
DS2 / REFLUX HERBA

Chicory is a herbaceous plant belonging to the Asteraceae family. Soluble plant fibres, including inulin and fructo-oligosaccharides (FOS), are extracted from its root. FOS are non-digestible soluble fibres that cannot get absorbed by the intestine. It’s here that they perform their prebiotic actions, in other words, promoting the growth and activity of Bifidobacterium and Lactobacillus, “good” bacteria – essential for our bodies’ digestive health. These bacteria use FOS to grow and reproduce, producing short-chain organic acids that inhibit pathogen growth.

Source(s): Gras Notice for short chain Fructoligosacchardes. Center for food safety. 13 June 2017

Product(s):DS1 / TERSUS

d

Damiana is a plant belonging to the Turneraceae family. The dry extract obtained from its leaves contains flavonoids, tannins and a bitter agent called damianin. The flavonoids are the plant’s active constituents, making it of valuable assistance in case of reduced libido or erectile dysfunction due to psychological causes, especially due to performance anxiety or premature ejaculation. They work on stimulating the spinal nerve centres, which control sexual organ function. It appears that they have a particular effect on the erectile function centre, located in the pelvic-sacral region of the parasympathetic nervous system.

Source(s):
Estrada-Reyes R, Ortiz-López P, Gutiérrez-Ortíz J, Martínez-Mota L. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males. J Ethnopharmacol. 2009;123:423–9

Product(s):
RPS2 / SUPREMUS SX

Devil’s claw is a perennial plant belonging to the Pedaliaceae family, used to treat joint pains, rheumatism, arthrosis and arthritis, thanks to its analgesic and anti-inflammatory properties. Its roots are rich in iridoid glycosides, harpagoside and procumbide functioning like NSAIDs (NonSteroidal Anti-Inflammatory Drugs), but without causing the same negative side effects on the stomach. They inhibit the activity of the COX-2 enzyme, preventing inflammatory cascade.

Source(s):
Assessment report on Harpagophytum procubens radix EMA/HMPC/627058/2015

Product(s):
MSS1 / ARNICA30
MSS2 / ARTUUM

Dog rose is a wild rose species belonging to the Rosaceae family. Its dry extract is rich in tannins, sugars, organic acids, flavonoids and vitamin C – giving it effective immunostimulant, anti-inflammatory and antioxidant activity. An excellent remedy in case of physical weakness or lack of energy, and during convalescence, because it eliminates feelings of fatigue and serves to balance mood. Vitamin C stimulates the immune defences especially during changes of season, and encourages the intestinal bacterial flora to form folic acid, thus facilitating iron absorption.

Source(s):
Therapeutic Applications of Rose Hips from Different Rosa Species Inés Mármol Cristina Sánchez-de-Diego Nerea Jiménez-Moreno,Carmen Ancín-Azpilicueta,and María Jesús Rodríguez-Yoldi. Int J Mol Sci. 2017 Jun; 18(6): 1137

Product(s):
IS3 / MIRABILUS IMMUNO PLUS
REVITALISING HERBAL TEA

e

Echinacea is a perennial belonging to the Asteraceae family. Used to stimulate the body’s immune defences, preventing infections in the upper respiratory tract and aiding other related treatments. Its immune stimulant activity is linked to its capacity to activate macrophages, which in turn regulate the activity of pro-inflammatory cytokines IL-6, IL-8 and TNF-alpha and thus helping to eliminate toxic substances. It has also been shown that its alkylamides bind to cannabinoid receptors, thus generating an immune-modulating effect. Promising studies have also shown it to have an antibacterial effect on Escherichia coli and on Pseudomonas aeruginosa.

Source(s):
Assessment report on Echinacea purpurea radix. EMA/MPC/424584/2016

Product(s):
RPS2 / SUPREMUS SX

Elder comes from the plant genus Sambucus, belonging to the Caprifoliaceae family. Elderberries are ideally suited in the treatment of urinary and respiratory tract inflammation, due to a high content of water (over 80%), mineral salts, carbohydrates, fibres, proteins and A, C and B-complex vitamins. If used on a regular basis, elderberry also aids the immune system. Its antibacterial and antiviral properties, having undergone rigorous scientific research, have shown its worth as an excellent remedy against seasonal flu-related ailments. It is capable of “isolating” the flu virus, preventing it from spreading throughout the body.

Source(s):
Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection Ji-Hye Lee, Mi Oh, Jong Hyeon Seok, Sella Kim, Dan Bi Lee, Garam Bae, Hae-In Bae, Seon Young Bae, Young-Min Hong, Sang-Oh Kwon, Dong-Hun Lee, Chang-Seon Song, Ji Young Mun, Mi Sook Chung, Kyung Hyun Kim Viruses. 2016 Jun; 8(6): 157

Product(s):
IS3 / MIRABILUS IMMUNO PLUS
REVITALISING HERBAL TEA

Eleuthero is a plant belonging to the Araliaceae family. The dried root extract is used in herbal medicine for its remarkable tonic and adaptogen properties. It contains a combination of eleutherosides, sterols, glucosides, coumarins, free phenolic acids and saponins, capable of stimulating the metabolism and rebalance energy. The use of this plant is ideal for people suffering from stress and overtiredness, physical weakness or lack of energy, during convalescence, mental and physical exhaustion, fatigue or low blood pressure. Also, whenever sportspeople require extra performance or during mentally challenging periods of studies i.e. preparing for exams, where extra concentration is required. In addition, the plant is rich in polysaccharides, which confer immune-modulating properties by increasing the number of T lymphocytes and bolstering white blood cell activity. It is ideal for preventing infectious diseases and different flu viruses, fighting off illnesses and increases the body’s resistance to colds.

Source(s):
Community herbal  monograph  on Eleutherococcus senticosus radix EMA/HMPC/680618/2013

Product(s):
MSS3 / SUPREMUS MIND

Eucalyptus is a plant belonging to the Myrtaceae family. The essential oil, obtained through the distillation of its leaves, possesses numerous therapeutic properties. Ideal as as a decongestant, because it reduces inflammation and calms nasal mucosae irritations, as well as working as an expectorant thinning phlegm and clearing out mucus. Also used in aromatherapy – inhalation helps relieve colds, sinusitis, stuffy noses and coughs. It also has an effective antibacterial activity against gram-positive and gram-negative bacteria, works as an antiviral against the herpes virus and has antifungal properties too.

Source(s):
Assessment report on Eucalyptus glubuls L. aetheroleum/HMPC/307782/2012

Product(s):
RS1 / SULFOSIN
RS5 / MIRABILUS PROFUNDUM
REVITALISING HERBAL TEA

f

Fennel is a perennial herb. Its essential oil is extracted by means of distillation. It possesses numerous therapeutic properties, for example: it aids digestion, is antispasmodic, carminative and diuretic. In fact, it stimulates the production and flow of bile, relaxing smooth muscle by directly working on regulation of the flow of calcium into cells. Ideal for individuals suffering from any type of intestinal problems, such as bloating, flatulence, aerophagia, abdominal cramps and hiccups.

Source(s):
Assessment report on Foeniculum volgaris miller aetheroleum/HMPC/263692/2006

Product(s):
DS3 / KILLCALORY
DIGESTIVE HERBAL TEA

FOS are non-digestible natural soluble fibres derived from Chicory (Cichorium intybus L.) that don’t get absorbed by the intestine. Thus, it is here that they perform their prebiotic actions, in other words, promoting the growth and activity of Bifidobacterium and Lactobacillus, “good” bacteria – essential for our bodies’ digestive health. These bacteria use FOS to grow and reproduce, producing short-chain organic acids that inhibit pathogen growth.

Source(s):
Gras Notice for short chain Fructoligosacchardes. Center for food safety. 13 June 2017

Product(s):
DS1 / TERSUS

g

Garcinia cambogia is a subtropical plant species belonging to the Clusiaceae family. Recent studies on its rind have revealed the presence of hydroxycitric acid (HCA). This compound plays an essential role in regulating body weight and appetite. It acts by inhibiting the synthesis of acetyl coenzyme A (acetyl-CoA), an energy substrate used by the body to synthesise cholesterol and other lipids. Thus reducing lipogenesis – the synthesis of new adipose tissue, and promoting lipolysis – the destruction of adipose tissue.

Source(s):
Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related gene expression in broiler chickens. Jing Han, Longlong Li, Dian Wang, Haitian Ma. Lipids Health Dis. 2016

Product(s):
M1 / SINE ADIPEM

Garlic is a bulbous plant belonging to the Liliaceae family. It contains numerous nutritional substances, such as mineral salts (magnesium, calcium, phosphorus, iodine and iron), vitamins (B1, B2, A, C and B3) and several active health beneficial ingredients. For instance, Allicin – which gives garlic its typical odour, is a scientifically recognised natural antibiotic substance. Numerous studies have highlighted the potential uses of Allicin in the medical sector, such as an antibacterial for gram-positive bacterial infections, reducing atherosclerosis and the formation of fat build-ups, as an antithrombotic, anti-inflammatory and antioxidant. Garlic, can therefore be thought of as a natural medicine for the general prevention of infections and for alleviating numerous seasonal ailments such as coughs, colds and the flu.

Source(s):
Assessment report on Allium cepa bulbus. EMA/HMPC/347195/2011

Product(s):
RS1 / SULFOSIN

Ginger is a herbaceous plant belonging to the Zingiberaceae family. The dried rhizome is the part containing the plant’s active constituents. Like its essential oil, which is mainly composed of zingiberene, gingerols and shogaols – being primarily responsible for its pungent flavour, as well as resins and mucilage. Clinical trials have highlighted that gingerols and shogaols affect the gastrointestinal 5-HT3 receptors and are responsible for ginger’s digestive properties. Stimulating gastric secretion and promoting the evacuation of the stomach. They are also excellent anti-inflammatories, inhibiting the inflammatory cascade, blocking certain (LOX and COX) enzymes that are important for the synthesis and release of prostaglandins.

Source(s):
Assessment report on Zingiber Officinale rhzoma EMA/HMPC/577856/2010

Product(s):
DS3 / KILLCALORY
IS3 / MIRABILUS IMMUNO PLUS
RS3 / MIRABILUS VOX

Grapes are the fruit coming from the common red grape vines (Vitis Vinifera). Numerous active constituents are extracted from the grape’s skin. The dry extract obtained is rich in polyphenols, in particular anthocyanins and proanthocyanidines bioflavonoids, which have antioxidant and anti-inflammatory activities. Their most important functions are as a tonic and vaso-protective for the circulatory system, having positive effects on blood vessel permeability, preventing oedema and swelling. Recommended in cases of phlebitis, capillary fragility, rosacea, oedema, haemorrhoids, cellulite, water retention, blood stasis and heaviness in the lower extremities.

Source(s):
Assessment report on Vitis vinifera folium  EMA/HMPC/464682/2016

Product(s):
RPS3 / PROSTAHELP

Grapefruit is extremely rich in vitamins, minerals and flavonoids renowned for its antibacterial and antimicrobial properties. Its antibacterial potency lies in its different mechanisms of action. It works against bacteria by attacking directly the cellular membrane. Microorganisms, so deprived of their external protective structure, suffer damage to their cytoplasm and become incapable of surviving in their surrounding environment. This mechanism eventually causes them to die. It affects yeasts by bringing about apoptosis, whereby the cells auto-destroy themselves. Thanks to these capabilities, grapefruit seed extract is noted for possessing excellent antibacterial, antiviral and antifungal properties. In addition, it contains vitamins A, C and E, giving it outstanding antioxidant properties.

Source(s):
J Altern Complement Med. 2002 Jun;8(3):333-40. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG

Product(s):
RS2 / MIRABILUS GOLA

Mastic is a gum-like resin obtained when making incisions into the lentisk’s or mastic tree’s trunk and branches. Because it contains polyphenols, terpenic acids and essential oils, it is an excellent natural remedy for the most common type of stomach ailments. Eliciting a soothing effect on the gastric mucosa and helping rebalance the production of gastric juices. Thus, ideal for quickly easing heartburn, as well as treating symptoms associated with acid reflux, gastritis and esophagitis. Numerous clinical trials have shown that it also has the ability to eliminate Helicobacter pylori from the stomach, killing it off by changing the bacterium’s structure.

Source(s):
Assessment report on Pistacia lentiscus  L., resin matrix EMA/HMPC/46756/2015

Product(s):
DS2 / REFLUX HERBA

GRAPEFRUIT SEED EXTRACT

Grapefruit is extremely rich in vitamins, minerals and flavonoids renowned for its antibacterial and antimicrobial properties. These traits are linked to the substances contained mainly in the fruit’s seeds, which are active against a wide range of harmful microorganisms. Indeed, its antibacterial potency lies in its different mechanisms of action. It works against bacteria by attacking directly the cellular membrane. Microorganisms, so deprived of their external protective structure, suffer damage to their cytoplasm and become incapable of surviving in their surrounding environment. This mechanism eventually causes them to die. It affects yeasts by bringing about apoptosis, whereby the cells auto-destroy themselves. Thanks to these capabilities, grapefruit seed extract is noted for possessing excellent antibacterial, antiviral and antifungal properties. In addition, it contains vitamins A, C and E, giving it outstanding antioxidant properties too.

Source(s):
J Altern Complement Med. 2002 Jun;8(3):333-40. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG

Product(s):
DS1 / TERSUS

Guarana is a shrub originally from the Amazon. Native Indian tribes have historically used it as an energising tonic. Its therapeutic effect is attributable to its seeds that have a notably high (10%) caffeine content. Caffeine accelerates fat burn off, boosting basic cell metabolism and thus facilitating the elimination of stored fats. It also stimulates the release of catecholamines such as adrenalin, enabling even faster, fat burn off. In addition, other compounds inside the seeds, have gastro-protective and antidepressant properties, and also improve physical and intellectual performance. All of this, without exciting or altering the heart’s natural rhythm.

Source(s):
Assessment report on Paulinia cupana Kunth ex H.B.K. var. sorbilis. EMA/HMPC/2011

Product(s):
M1 / SINE ADIPEM
MSS3 / SUPREMUS MIND
RPS2 / SUPREMUS SX

h

Hawthorn is a perennial belonging to the Rosaceae family. The extract obtained from its leaves and flowers contains a mixture of active constituents – the two most important being hyperoside and vitexin. Both have strong cardio-protective activities, because they induce dilation of the coronary arteries supplying blood to the heart, thus improving blood flow and consequently reducing blood pressure. They reduce tachycardia and arrhythmia in nervous and anxious people. Moreover, vitexin acts as a natural spasmolytic, sedative and anxiolytic. It is particularly beneficial for patients who are extremely anxious, reducing their emotional sensitivity when they are suffering from stress, anxiety or distress, as well as insomnia.

Source(s):
Assessment report on Crataegus spp., folium cum flore EMA/HMPC/159076/2014

Product(s):
NS1 / SERENIS

He Shou Wu, native to Southern Central China, is a powdered root extract from Polygonum multiflorum, which has been used in Traditional Chinese Medicine for millennia to prevent signs of ageing. Its phytocomplex is a true superfood, comprised of numerous active constituents: anthraquinones, anthrone, chrysophanic acid, emodin, rhein, physcion, digitolutein, lecithin, rhaponticin, beta-sitosterol, catechins, cyanidins, calcium, iron, zinc, manganese and others. Its main effect is linked to its ability to support and promote recovery and maintenance of brain faculties and helping with memory. It also provides effective support during periods of anxiety, stress, insomnia and nervousness. Its strength lies in its remarkable ability to purify the body cleansing the kidneys and liver, which in turn cleanse the blood. It is also excellent for treating joint pain (especially lumbar and knee) and more generally for keeping the body young. It is rich in natural antioxidants, which combat the activity of free radicals, preventing inflammation and pain while at the same time increasing clarity of mind.

Source(s):
Kim HN, Kim YR, Jang JY, Choi YW, Baek JU, Hong JW, Choi YH, Shin HK, Choi BT. “Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells.” J Ethnopharmacol

Product(s):
IS1 / ANTOXI PLUS
IS2 / ANTOXI PLUS FLUID
MSS3 / SUPREMUS MIND
RPS2 / SUPREMUS SX

Hedge mustard is a plant belonging to the Brassicaceae family, commonly known as the “singers’ plant” due to its anti-inflammatory and mucolytic effects on the respiratory tract. It is particularly ideal in treating throat inflammations, and aphonia or dysphonia (hoarseness or temporary voice loss) due to laryngitis, pharyngitis or tracheitis. Clinical trials attribute these healing properties to the presence of mucilage and sulphur compounds, making hedge mustard a mucolytic and expectorant for bronchial secretions.

Source(s):
Assessment report on Sisymbrium officinale herba. EMA/MPC/280194/2013

Product(s):
RS3 / MIRABILUS VOX

Hibiscus is a member of the mallow family, a plant native to Asia. Often used as a herbal infusion, due to its high concentration of vitamin C and antioxidant properties. Hibiscus extract has a relaxing effect on the muscles, and scientific studies have shown it is capable of lowering high blood pressure.

Source(s):
María Herranz-López, Mariló Olivares-Vicente, Marina Boix-Castejón, Nuria Caturla, Enrique Roche, and Vicente Micol. Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial. Sci Rep. 2019; 9: 2999.

Product(s):
REVITALISING HERBAL TEA

Honey is an extremely complex substance, rich in essential constituents making it a true nutritional supplement. Mainly made up of sugars, it also contains numerous mineral salts and vitamins, especially B group & C vitamins, plus folic acid and pantothenic acid. It also contains antibiotic constituents, amino acids, proteins, hormones, enzymes and more. For this reason, honey offers numerous benefits. It works as a decongestant and relieves coughs, it increases physical strength and endurance, has cardio-tropic properties, prevents damage to the liver (hepatoprotective) and detoxifying, stimulates and regulates the digestive system, and has anti-anaemic activity.

Source(s):
Medical benefit of honeybee products. José Mauricio Sforcin, Vassya Bankova, Andrzej K. Kuropatncki. Evid Based Complement Alternat. Med 2017; 2017: 2702106

Product(s):
IS2 / ANTOXI PLUS FLUID
IS3 / MIRABILUS IMMUNO PLUS
MSS2 / SUPREMUS MIND 
RPS2 / SUPREMUS SX
RS2 / MIRABILUS GOLA
RS3 / MIRABILUS VOX
RS5 / MIRABILUS PROFUNDUM

Horehound is a perennial plant belonging to the Labiatae family. It contains many substances, including essential oils, diterpenes, tannins and flavonoids – making it useful as an antispasmodic, anti-inflammatory and analgesic. Horehound works by inhibiting the activity of numerous neurotransmitters, such as acetylcholine, bradykinin, prostaglandin E2, histamine and oxytocin. It has always been used in traditional medicine, as an expectorant, a diuretic and as a carminative thanks to marrubin a bitter substance working on the respiratory and gastrointestinal tracts.

Source(s):
Assessment report on Marrubium vulgare herba. EMA/HMPC/604273/2012

Product(s):
RS5 / MIRABILUS PROFUNDUM

Hyssop is a plant belonging to the Lamiaceae family, used to ward off coughs, colds and asthma. Its flowering tips contain flavonoids, tannins, a bitter substance called marrubin and a very pleasant essential oil – mainly responsible for its balsamic and expectorant properties.

Source(s):
A review on Hyssopus officinalis L.: composition and biological activities. Fatemeh Fathiazad and Sanaz Hamedeyazdan. African Journal of Pharmacy and Pharmacology Vol. 5(17), pp. 1959-1966, 8 November, 2011

Product(s):
RS3 / MIRABILUS VOX
RS5 / MIRABILUS PROFUNDUM

l

Lapacho is a native Brazilian tree and has been used as a medicinal herb for thousands of years. The main properties of Lapacho are antibacterial, anti-inflammatory, antioxidant and purifying. All thanks to a substance called lapachol, found in the tree’s bark. Proven to be effective against gram-negative and gram-positive bacteria, e.g. Staphylococcus and Streptococcus. Also, beneficial in cases of intestinal inflammation – some studies have reported promising results in the treatment of intestinal polyps, although the working mechanism it employs is not yet known.

Source(s):
Comparison of antibacterical and antifungal activities of lapachol and b-lapachone. Pascale Guiraud, Régine Steiman, Campos-Takaki GM, Seigle-Murandi F, Simeon de Buochberg M.

Product(s):
DS1 / TERSUS
IS3 / MIRABILUS IMMUNO PLUS

Lemon balm is a perennial herbaceous plant belonging to the Labiatae family, known for its calming and sedative effects. The dried leaf extract is rich in polyphenols, coumarins and triterpenic acids, proven to have antispasmodic, anti-inflammatory and carminative properties and suited in cases of neuralgia, digestive disorders and nausea. Its essential oil, on the other hand, affects the central nervous system – binding to GABA-receptors. It has a soothing effect on the nervous system and relaxes muscles. Recommended for general irritability, insomnia brought on by excessive fatigue and nervousness.

Source(s):
Assessment report on Melissa officinalis folium EMA/HMPC/196746/2012

Product(s):
NS1 / SERENIS
RELAXING HERBAL TEA

Lentisk is an evergreen shrub belonging to the Anacardiaceae family. It oozes a gum-like resin, called mastic, when cutting into its trunk or branches. Because it contains polyphenols, terpenic acids and essential oils, it is an excellent natural remedy for the most common type of stomach ailments. Eliciting a soothing effect on the gastric mucosa and helping rebalance the production of gastric juices. Thus, ideal for quickly soothing heartburn, as well as treating symptoms associated with acid reflux, gastritis and esophagitis. Numerous clinical trials have shown that it also has the ability to eliminate Helicobacter pylori from the stomach, killing it off by changing the bacterium’s structure.

Source(s):
Assessment report on Pistacia lentiscus  L., resin matrix EMA/HMPC/46756/2015

Product(s):
DS2 / REFLUX HERBA

Liquorice is a perennial herbaceous plant belonging to the Fabaceae family. Often used in candies or liqueurs, it boasts numerous therapeutic properties, thanks to the elevated number of active constituents it contains. Glycyrrhizin and carbenoxolone, found mainly in the root, have been identified as having an antiulcer effect in both the stomach and the duodenum. Indeed, they decrease the secretion of gastric juices by inhibiting the release of gastrin, a hormone found in the gastric mucosa that regulates the release of hydrochloric acid.

Source(s):
Assessment report on Glycyrrhiza glabra L. and/or Glycyrrhiza inflata Bat. And/or Glycyrrhiza uralensis Fisch. Radix EMA/HMPC/571122/2010

Product(s):
DS2 / REFLUX HERBA
MSS1 / ARNICA30
MSS2 / ARTUUM
RS2 / MIRABILUS GOLA
RS3 / MIRABILUS VOX
RS4 / MIRABILUS PETTORALIS
DETOXIFYING HERBAL TEA
DIGESTIVE HERBAL TEA

Lovage or also commonly known as mountain celery, is a perennial plant often used as a cooking spice due to its special pungent flavour. The roots and leaves are the most commonly used parts of the plant. Rich in polyphenols, Lovage functions as an antioxidant and anti-inflammatory. Scientific studies have also shown that Lovage has antibacterial and hepato-protective properties. It is mainly used in natural medicine for its diuretic, digestive and tonifying properties.

Source(s):
Antioxidative and Potentially Anti-inflammatory Activity of Phenolics from Lovage Leaves Levisticum officinale Koch Elicited with Jasmonic Acid and Yeast Extract. Urszula Złotek, Urszula Szymanowska, Łukasz Pecio, Solomiia Kozachok,and Anna Jakubczyk. Molecules. 2019 Apr; 24(7): 1441

Product(s):
DETOXIFYING HERBAL TEA

m

Mallow is a plant native to Europe, North Africa and Asia. Its use in traditional natural medicine dates back to 3,000 BC. The most commonly used parts of mallow plant are its leaves, petals and aerial parts. Its principal actions include antioxidant, anti-inflammatory and antiulcerogenic activity and skin tissue regeneration. Mallow is mainly used to treat gastrointestinal disorders, abdominal pain and respiratory diseases.

Source(s): Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine. João Cleverson Gasparetto, Cleverson Antônio Ferreira Martins, Sirlei Sayomi Hayashi, Michel Fleith Otuky, and Roberto Pontarolo. Journal of Pharmacy And Pharmacology.

Product(s):
DETOXIFYING HERBAL TEA

Marsh-mallow is a plant belonging to the Malvaceae family. Extracts from its root contain starch, pectins, mucilage, sugars, fats and tannins. Mucilage, in particular, gives the plant emollient, soothing and protective properties for mucous membranes. Thus, ideal for treating all forms of inflammation, such as sore throats, abscesses, stomatitis and gingivitis. The plant’s decongestive and anti-inflammatory effects on the body’s soft tissues makes it an efficacious remedy for treating respiratory tract ailments, such as coughs and colds. Ideally as a cough suppressant, rhamnogalacturonan has been shown to act on 5-HT2 serotonin receptors, helping inhibit them.

Source(s):
Assessment report on Althaea officinalis radix. EMA/MPC/436680/2015

Product(s):
RS3 / MIRABILUS VOX
RS4 / MIRABILUS PETTORALIS

Meadowsweet is a plant belonging to the Rosaceae family, known for its anti-inflammatory and diuretic properties. Its phytocomplex contains salicylic derivatives (salicylaldehyde, methyl salicylate, ethyl salicylate), flavonoids, vitamin C, essential oils and mineral salts. Meadowsweet has anti-inflammatory, pain-relieving and fever-reducing activity, because it inhibits the synthesis of prostaglandins (PGE2), which are responsible for pain and for the tissues’ inflammatory process. For this reason, it is called the “vegetable aspirin” along with willow. However, unlike synthetic anti-inflammatories, it is not ulcerogenic (does not cause gastritis or ulcers), since the presence of mucilage gives meadowsweet a protective effect on the mucosae, capable of reducing cramping and erosion of the gastric lining.

Source(s):
Assessment report on Filipendula ulmaria flos. EMA/HMPC/434892/2010

Product(s):
MSS1 / ARNICA30
MSS2 / ARTUUM
RPS3 / PROSTAHELP

Methylsulfonylmethane is a mineral, an organosulfur compound, used as a nutritional food supplement because of its anti-inflammatory and antioxidant properties. In fact, it affects the cellular inflammatory cascade, reducing prostaglandins and interleukins levels, and other types of pro-inflammatory cytokines – molecules that play an active role in regulating the inflammatory processes. Given that it is also a source of highly bioavailable sulphur, it donates this molecule to the methyl groups of molecules active in healing processes, such as glutathione, a powerful antioxidant and deactivator of free radicals that is normally present in the immune system.

Source(s):
Methylsulfonylmethane is effective against gastric mucosal injury. KeyvanAmirshahrokhiaAli-RezaKhalilib. European Journal of Pharmacology Volume 811, 15 September 2017, Pages 240-248

Product(s):
DS1 / TERSUS
MSS1 / ARNICA30

Mint is a perennial herbaceous plant about 50-60 cm in height with a fibrous rhizome. Renowned and used for culinary as well as therapeutic purposes – mainly thanks to its high menthol content, since ancient times. The most active compound of its phytocomplex, is contained in its essential oil. In vitro studies have shown it works as an antispasmodic on intestinal tissue, inhibiting spontaneous contractility of the colon and affecting the inflow of intracellular calcium. Particularly suited for irritable bowel syndrome. Menthol has also proven to have bronchomucotropic properties, meaning that it stimulates cell mucus production in the bronchia.

Source(s):
Assessment report on Mentha piperita aetheroleum. EMA/HMPC/349465/2006

Product(s):
DS3 / KILLCALORY
RS2 / MIRABILUS GOLA
RS3 / MIRABILUS VOX
DIGESTIVE HERBAL TEA/a>
REVITALISING HERBAL TEA

Milkwort is a herbaceous plant belonging to the Polygalaceae family. Known for its laxative, expectorant, emollient and stomachic properties. Its useful therapeutic effects are due to the presence of polygaline, saponins, tannins, mucilage, and glycoside gualtherin. Taken in therapeutic doses, it is generally used as an expectorant, and is therefore highly suited to cases of coughs, whooping cough, colds, asthma, bronchitis, and respiratory diseases. Milkwort also stimulates urination and sweating, which helps in the event of fever. Milkwort also has a laxative effect, and is therefore beneficial in treating intestinal problems, promoting the expulsion of wastes harmful to the body.

Source(s):
LODI V., Fitoterapia, 16, 41, 1940

Product(s):
RS1 / SULFOSIN
RS3 / MIRABILUS VOX
RS5 / MIRABILUS PROFUNDUM

Moringa is a plant belonging to the Moringaceae family. It is of remarkable interest from a nutritional standpoint, given that the plant’s protein content is complete – it contains the entire range of amino acids necessary to meet the recommended protein intake. Easily defined as a super-food. In terms of as an antioxidant, it has proven to be, as effective, as vitamin C..

Source(s):
An Investigation of the Antioxidant Capacity in Extracts from Moringa oleifera Plants Grown in Jamaica. Racquel J. Wright Ken S. Lee Hyacinth I. Hyacinth,Jacqueline M. Hibbert Marvin E. Reid Andrew O. Wheatley,and Helen N. Asemota. Plants (Basel). 2017 Dec; 6(4): 48

Product(s):
IS2 / ANTOXI PLUS FLUID

Mouse-ear hawkweed belongs to the Asteraceae family. The aerial plant parts are the parts most typically used and contain phytochemicals such as coumarins, flavonoids, triterpenes and tannins. Usually known for its diuretic, antibiotic and anti-inflammatory properties and as such is mainly used in natural medicine to treat swellings, oedemas, water retention and urinary tract infections.

Source(s): https://www.floraitaliae.actaplantarum.org/viewtopic.php?f=95&t=3417 EMA/HMPC/437859/2010

Product(s):
DETOXIFYING HERBAL TEA

Muira puama, or Marapuama, is a plant common in Brazil and famous for its aphrodisiac effects. The dried leaf extract contains substances rich in fatty acids and essential oils – including beta-caryophyllene and alpha-humulene. As well as plant sterols and triterpenes – including lupeol. There is one substance of particular interest, an alkaloid called muirapuamin, with specific vasodilatory properties. It affects the “catecholaminergic” system in the central nervous system and is able to generate a feeling of energy\overall physical vitality. Whilst, Muira puama’s sterols work on the activation of the testosterone hormone receptors, enhancing libido and improving sexual performance.

Source(s):
Wayneberg J. Yohimbine vs Muira puama in the treatment of erectile dysfunction. The American J of Natural Medicine 1994;1:8-9

Product(s):
RPS2 / SUPREMUS SX

n

Nettle is a plant belonging to the Urticaceae family. The extracts obtained from the nettle leaves are rich in caffeic acid, with diuretic and anti-inflammatory properties. Caffeic acid inhibits leukotriene synthesis and the production of inflammatory prostaglandins. The presence of lignans and lectins has been shown to have an effect in cases of benign prostatic hyperplasia, although the exact mechanism of action enabling it to have this activity, is still not fully understood. One in vitro study showed that it is capable of inhibiting SHBG (Sex Hormone Binding Globulin) from binding to the prostate tissue receptors and inhibiting aromatase enzyme activity, located in the prostate. Thus, suitable for prostatitis and benign prostatic hyperplasia.

Source(s):
Assessment report on Urtica dioica, Urtica urens, folium. EMA/HMPC/508013/2006

Product(s):
RPS3 / PROSTAHELP

Niaouli is a plant belonging to the Myrtaceae family. Its essential oil, obtained through the distillation of its leaves, possesses numerous therapeutic properties. It is used as an antibacterial, for instance in skin formulations to treat acne, as an antifungal to treat oral candidiasis or nail fungus, and as an antiviral for cold-sore therapy. Both in vivo and in vitro studies have shown that this oil interacts with the pathogen’s cell walls, destroying it.

Source(s):
Assessment report on Melaleuca alternifolia (Maiden and Betch) Cheel, M. linariifolia Smith, M. dissitiflora F. Mueller and/or other species of Melaleuca, aetheroleum EMA/HMPC/320932/2012

Product(s):
RS1 / SULFOSIN
RS2 / MIRABILUS GOLA
RS3 / MIRABILUS VOX
RS4 / MIRABILUS PETTORALIS

o

Orange tree blossoms, which bloom in temperate climates, are often used to decorate sweets or add flavour to beer. Ancient legends talk of this flower and describe it as a symbol of good luck for weddings. A number of different compounds with sedative effects have been isolated from orange blossoms. These beneficial properties help the body relax and alleviate stress and anxiety.

Source(s):
Pharmacological Exploration of the Sedative Mechanism of Hesperidin Identified as the Active Principle of Citrus sinensis Flowers. Silvia Laura Guzmán-Gutiérrez, Andrés Navarrete. Planta Med 2009; 75(4): 295-301

Product(s):
RELAXING HERBAL TEA

p

Papaya is a plant belonging to the Caricaceae family, well-known for its characteristic yellow-orange fruit. The health benefits of its fruit’s extract can be attributed to the presence of a digestive enzyme called papain, capable of breaking down proteins. Making it highly beneficial for people with digestive problems i.e. after fatty and protein rich meals, and gastritis or gastroduodenitis sufferers. Clinical trials have confirmed that papaya provides excellent support in the treatment of inflammation and effective immunostimulant.

Source(s):
Anti-inflammatory and immunomodulatory properties of Carica papaya. Saurabh Pandey, Peter J. Cabot, P. Nicholas Shaw & Amitha K. Hewavitharana JOURNAL OF IMMUNOTOXICOLOGY, 2016

Product(s):
DS1 / TERSUS

Passion Flower is a plant belonging to the Passifloraceae family. Thanks to its soothing effect, it is one of the most frequently used phytotherapeutic remedies for nervous disorders. Its aerial parts contain alkaloids and flavonoids, affecting the central nervous system and especially the spinal cord – controlling movement and sleep centres. Recent studies have shown its active constituents are able to bind directly to the brain’s benzodiazepine receptors. Inducing physiological sleep, preventing night awakenings but without causing sluggishness the morning after. It doesn’t have any narcotic effects and isn’t addictive. Suitable for stress, anxiety and anxiousness, as well as in hysteric, phobic, obsessive and post-traumatic neuroses.

Source(s):
Assessment report on Passiflora incaranata, herba flore EMA/HMPC/669738/2013

Product(s):
NS1 / SERENIS
RPS1 / ADHUC

See also: Bromelain.

Pineapple is a plant belonging to the Bromeliaceae family. A proteolytic enzyme called bromelain, is extracted from the plant’s flesh and stem. Bromelain, is used medicinally as an anti-inflammatory and antioedemic. Bromelain is safer than other anti-inflammatories due to differences in the action mechanism. NSAIDs inhibit cyclooxygenase, blocking prostaglandin synthesis, while bromelain “diverts” the synthesis, increasing the production of anti-inflammatory prostaglandins to the detriment of pro-inflammatory prostaglandins, thus preventing the gastrointestinal damage typically caused by NSAIDs.

Source(s):
Properties and Therapeutic Application of Bromelain: A Review. Rajendra PavanSapna JainShraddha, and  Ajay Kumar. Biotechnol Res Int. 2012; 2012: 976203

Product(s):
RPS3 / PROSTAHELP

The poppy is a very common flower in Italy. The flower’s red petals are the most frequently used parts. It contains alkaloids, including rhoeadine, which gives it its soothing and sedative properties. Making this plant perfect for people looking to relax.

Source(s):
https://www.floraitaliae.actaplantarum.org/viewtopic.php?f=95&t=12032

Product(s):
RELAXING HERBAL TEA

The Prickly Pear is a succulent plant belonging to the Cactaceae family. The purified pulp obtained from the leaves is rich in opuntiamannans – polysaccharides capable of binding ingested fats and sugars, making it harder for the body to absorb them, enabling the body to expel them without being able to use them.

Source(s):
Effects of Cactus Fiber on the Excretion of Dietary Fat in Healthy Subjects: A Double Blind, Randomized, Placebo-Controlled, Crossover Clinical Investigation Ralf Uebelhack, MD, PhD,1 Regina Busch,2 Felix Alt,2 Zhi-Ming Beah,3, and  Pee-Win Chong3Curr Ther Res Clin Exp. 2014 Dec; 76: 39–44

Product(s):
DS3 / KILLCALORY

Propolis is a resinous substance produced by bees. Comprising more than 300 constituents, such as resins, balsams and waxes – which can vary depending on the harvest source. In addition, there are also aromatic acids, pollens, essential oils, flavonoids, polyphenols, mineral salts and B-group vitamins – making it a true natural medicine. Numerous studies have focused on propolis, given that it possesses anti-inflammatory, antiviral, antimicrobial, antifungal and immune-modulating activity. With regard to immunomodulation, it has been observed that propolis modulates the expression of a number of receptors active in the pro-inflammatory cascade at the genetic level, as well as modulating macrophage activity.

Source(s):
Búfalo, M. C., Bordon-Graciani, A. P., Conti, B. J., de Assis Golim, M., & Sforcin, J. M. (2014). The immunomodulatory effect of propolis on receptors expression, cytokine production and fungicidal activity of human monocytes. Journal of Pharmacy and Pharmacology, 66(10), 1497–1504

Product(s):
RS2 / MIRABILUS GOLA
RS4 / MIRABILUS PETTORALIS

r

Resveratrol is a plant compound, a polyphenol produced naturally in red grape skin and some berries protecting them from stressful environmental conditions such as pathogens, UV rays, water stress, etc. Its effect in humans has also been studied, acting as a powerful antioxidant and anti-inflammatory. The trans-Resveratrol form – which is more readily available – has in fact been demonstrated to be able to inhibit lipid peroxidation i.e. lowering LDL. It is also a chelating agent for metal ions and counters free radicals. Acting as an anti-inflammatory, it is effective against cytokines and inflammatory proteins, blocking the inflammatory signal transduction cascade at cellular level.

Source(s):
Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes Sabrina Fabris, Federico Momo, Giampietro Ravagnani, Roberto Stevanato Biophysical Chemistry 135 (2008) 76–83

Product(s):
IS1 / ANTOXI PLUS

Grapes are the fruit coming from the common red grape vines (Vitis Vinifera). Numerous active constituents are extracted from the grape’s skin. The dry extract obtained is rich in polyphenols, in particular in anthocyanins and proanthocyanidines bioflavonoids, which have antioxidants and anti-inflammatory activities. Their most important function is as a tonic and vaso-protective for the circulatory system, having positive effects on blood vessel permeability, preventing oedema and swelling. Recommended in cases of phlebitis, capillary fragility, rosacea, oedema, haemorrhoids, cellulite, water retention, blood stasis and heaviness in the lower extremities.

Source(s):
Assessment report on Vitis vinifera folium EMA/HMPC/464682/2016

Product(s):
RPS3 / PROSTAHELP

Rhodiola is a plant belonging to the Crassulaceae family. The dried root extract contains phenylpropanoid glycosides – salidroside and rosavin, in particular. These active constituents increase beta-endorphins’ plasma concentrations, which in turn are able to prevent hormonal fluctuations associated with stress. Working at central nervous system level, increasing serotonin and dopamine concentrations. They have proven to have adaptogen activity – meaning individuals are more easily able to adapt to stressful emotional situations i.e. maintaining better cognitive performance e.g. during exams or work-related stress. Helpful in restoring calm and eliminating inner tensions.

Source(s):
Assessment report on Rhodiola rosea rhizoma ed radix EMA/HMPC/232100/2011

Product(s):
NS1 / SERENIS

Ribwort plantain is a plant belonging to the Plantaginaceae family. The dry leaf extract contains glucosides, flavonoids (luteolin), mucilage, tannins, pectins, salicylic acid and mineral salts. These active constituents give the plant expectorant, antibacterial and anti-inflammatory properties. The latter is due to aucubin, which, through hydrolysis releases aucubigenin. An active constituent with anti-allergenic and decongestant properties, whose mechanism of action is based on inhibiting the synthesis of inflammatory mediators. In addition, aucubigenin hinders the proliferation of the Staphilococcus aureus bacterium, making it a useful bacteriostatic remedy. Ribwort plantain is suitable in treating general respiratory tract inflammations and coughs, bronchial phlegm and chronic bronchitis.

Source(s):
Assessment report on Plantago lanceolata folium. EMA/HMPC/437859/2010

Product(s):
RS4 / MIRABILUS PETTORALIS

Royal jelly is a bitter tasting, gelatinous-like substance, produced by bees as nourishment for their queen bee. It is mainly made up of water, proteins, sugars and mineral salts. Royal jelly also contains a broad range of B vitamins including B3, and vitamin C. In addition to being a rich and rather complete form of nourishment, scientific analyses have also shown that it contains several proteins with antimicrobial properties, highly efficient against gram-positive bacteria. Thanks to these properties, royal jelly is able provide relief from bacterial infections, reducing inflammation. It also has a stimulating effect on the immune system, an additional benefit in the event of an immune response. Furthermore, royal jelly has antioxidant properties, protecting the body from the stress caused by free radicals and their subsequent problems – including infertility and psychophysical stress.

Source(s):
Royal Jelly: An ancient remedy with remarkable antibacterial properties. Filippo Fratini, Giovanni Cilia, Simone Mancini, Antonio Felicioli. Microbiological Research 2016; Vol. 192; pag 130-141.

Royal jelly decreases corticosterone levels and improves the brain antioxidant system in restraint and cold stressed rats. Renata RolandTeixeira, Adriele Vieirade Souza, Leonardo Gomes Peixoto, Helen Lara Machado, Douglas Carvalho Caixeta, Danielle Diniz Vilela, Nathalia Belele Baptista, Celso RodriguesFranci, Foued Salmen Espindola. Neuroscience Letters Volume 655, 10 August 2017, Pages 179-185.

Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. Heni Susilowati, Keiji Murakami, Hiromichi Yumoto, Takashi Amoh, Kouji Hirao, Katsuhiko Hirota, Takashi Matsuo, and Yoichiro Miyake. Biomed Res Int. 2017; 2017: 3191752.

Antioxidant Activity of Royal Jelly Hydrolysates Obtained by Enzymatic Treatment. Hyejung Gu, In-Bong Song, Hye-Ju Han, Na-Young Lee, Ji-Yun Cha, Yeon-Kyong Son, and Jungkee Kwon. Korean J Food Sci Anim Resour. 2018 Feb; 38(1): 135–142.

Supplementation with Major Royal-Jelly Proteins Increases Lifespan, Feeding, and Fecundity in Drosophila. Xin XX, Chen Y, Chen D, Xiao F1, Parnell LD, Zhao J, Liu L, Ordovas JM, Lai CQ, Shen LR. J Agric Food Chem. 2016 Jul 27;64(29):5803-12.

Product(s): MSS3 / SUPREMUS MIND

s

Sage is a plant belonging to the Lamiaceae family. The dried leaf extract contains numerous active constituents such as phenolic acids, flavonoids, and an essential oil – containing thujone, cineole, borneol, linalool, beta-terpineol, and beta-caryophyllene. Thanks to the presence of “phytoestrogens”, it also possesses oestrogenic properties i.e. similar to female hormones, binding to oestrogen receptors. It regulates menstrual cycles, alleviates pre- and post-menstrual symptoms and the symptoms of menopause, such as hot flashes. Sage is also used in the treatment of gastrointestinal disorders, relaxing smooth muscles via its antispasmodic activity – suitable for irritable bowel syndrome, digestive system spasms and menstrual pain. Carnosic acid and triterpenes (amyrin, betulin, maslinic acid, and 3-hydroxy-ursolic acid) in sage give it anti-inflammatory and diuretic properties, providing an effective response to water retention, oedema, rheumatism and headaches. Lastly, the European Commission has recognised Sage as an effective way to treat excessive perspiration.

Source(s):
Assessment report on Salvia officinalis folium EMA/HMPC/150801/2015

Product(s):
RPS1 / ADHUC

Saw palmetto is a plant belonging to the Arecaceae family. The active constituents contained in its fruit are sterols (beta-sitosterols), free fatty acids, carotenoids, essential oils and polysaccharides. Its phytocomplex mechanism of action is reliant on the beta-sitosterol activity – inhibiting the 5-alpha H-reductase enzyme, which plays a role in transforming testosterone into dihydrotestosterone. The plant therefore has an effect on the prostate tissue cells, limiting cell proliferation causing the prostate to enlarge and become inflamed. This congestion and volume increase puts pressure on the bladder and compresses the urethra, making it more difficult to urinate as well as stimulating the urge to urinate more frequently. Beneficial when treating male urogenital system diseases, and stage-1 and stage-2 benign prostatic hyperplasia (BPH) – where urinary symptoms and “dysuria” predominate.

Source(s):
Assessment report on Serenoa repens fructus. EMA/HMPC/137250/2013

Product(s):
RPS3 / PROSTAHELP

Scots pine is an evergreen tree belonging to the Pinaceae family. Through the distillation of its leaves, an essential oil can be obtained – having numerous therapeutic properties. Ideal as an expectorant because, when inhaled it helps thin phlegm – making it easier to get rid of. Suitable for colds, sinusitis, flu, cough, laryngitis, acute or chronic bronchitis, flu-like syndromes and asthma.

Source(s):
Chemical composition and antimicrobial activity of the essential oils of Pinus pinaster . Nouara Ait Mimoune, Djouher Ait Mimoune, Aziza Yataghene . Journal of Coastal Life Medicine 2013; 1(1): 55-59

Product(s):
RS1 / SULFOSIN
RS5 / MIRABILUS PROFUNDUM

Schisandra is a woody, vine climbing plant whose fruit is famous for its “five flavours”. Its berries, in fact, taste sour, sweet, salty, bitter and tangy all at the same time. This is due to a composition of mainly one very rich essential oil – containing many types of acids such as citric and malic, monosaccharides, resin, pectin, phospholipids, tannins, sterols and a considerable quantity of vitamins A, C and E. Five-flavour-fruit or Chinese magnolia vine berry is renowned for being an excellent antioxidant and adaptogen. Its active constituents have beneficial effects on the body, helping it to “adapt” to highly stressful periods or seasonal changes.

Source(s):
Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice. Cheng N, Ren NGao HLei XZheng JCao W. Food Chem Toxicol. 2013 May;55:234-40. doi: 10.1016/j.fct.2012.11.022. Epub 2012 Nov 28

Product(s):
IS2 / ANTOXI PLUS FLUID
RPS2 / SUPREMUS SX

Seaberry is a thorny shrub renowned mainly for its small orange berries rich in vitamins A, B, C and E, trace elements such as calcium, iron, phosphorous, magnesium, potassium and sodium, carotenoids and flavonoids, folic acid, and omega 3, 6 and 9. Its vitamin-C content is higher than that found in citrus or kiwifruit, making it an excellent adaptogen suitable for periods of stress, fatigue, and physical weakness or lack of energy. It is a good immunostimulant and immunomodulator.

Source(s):
Possible mechanism of adaptogenic activity of seabuckthorn (Hippophae rhamnoides) during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats. Saggu S Kumar R. Food Chem Toxicol. 2007 Dec;45(12):2426-33. Epub 2007 Jun 23

Product(s):
IS2 / ANTOXI PLUS FLUID

Stevia is a native South American plant, its leaves frequently used as a beverage sweetener thanks to stevioside and rebaudioside glycosides. These glycosides can’t be absorbed by the human body nor attacked by the oral bacterial flora, they have no nutritional value and do not increase blood glucose levels. Making it highly suitable for diabetics. In the large intestine, they are metabolised into steviol, the main aglycone – which is expelled as glucuronide in the urine, following a slight absorption. Furthermore, stevia leaves keep blood cholesterol levels stable, are calorie free and adjuvants for many types of programmes such as weight loss plans, as well as tonifying, stomachic, hypoglycemic, hypotensive, antimicrobial and epidermotropic ones. Since 17 June 2017, stevia has been included in the List of Novel Foods and identified as a traditional food.

Source(s):
S. K. GOYAL. Stevia (Stevia rebaudiana) a biosweetener: A review. International Journal of Food Sciences and Nutrition · December 2009

Product(s):
DETOXIFYING HERBAL TEA
RELAXING HERBAL TEA
DIGESTIVE HERBAL TEA

Sodium alginate is a polysaccharide derived from algae. When ingested, it chemically reacts with hydrochloric acid to form an alginic acid mucilage. This gel, with an almost neutral pH, impedes acid reflux and thus protecting the gastric mucosa and the oesophagus.

Source(s):
Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis D. A. Leiman, B. P. Riff, S. Morgan, D. C. Metz, G. W. Falk, B. French, C. A. Umscheid, and J. D. Lewis. Dis Esophagus. 2017 May; 30(5): 1–9

Product(s):
DS2 / REFLUX HERBA

Hyaluronic acid is a fundamental connective tissue component, especially for skin and mucosae. The amount of this acid produced, decreases with age. Thus, to prevent and to reduce signs of aging, the fragmented plant-derived active constituent can be used in both oral and topical formulations. This active constituent is an effective antioxidant, especially when considering tissue damage is made worse by free radicals because of inflammation. In fact, it works at the cells’ genetic level, increasing the expression of TGF-1, a mediator that stimulates the migration, metabolism and proliferation of fibroblasts and keratinocytes – the cells that carry out cell repair.

Source(s):
Matsiko, A., Levingstone, T. J., Gleeson, J. P., & O’Brien, F. J. (2015). Incorporation of TGF-Beta 3 within Collagen-Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential. Advanced Healthcare Materials, 4(8), 1175–1179

Product(s):
IS1 / ANTOXI PLUS

Soy is an herbaceous plant belonging to the Leguminosae family. Its dried seed extract is rich in phytoestrogens like isoflavones, genistein and daidzein – binding to oestrogen receptors, imitating and modulating their action. Displaying positive impacts on sudden hormone level changes and alleviating menopause ailments i.e. hot flashes, osteoporosis, heart palpitations.

Source(s):
Assessment report on Glycine max semen EMA/HMPC/461813/2016

Product(s):
RPS1 / ADHUC

Spirulina is an alga belonging to the Cyanophyceae class, shaped like a helix. Rich in proteins, vitamins and minerals and is able to satisfy most of the body’s daily iron and pro-vitamin A requirements. Often used in the food industry because of its nutritional value. Scientific studies have shown that spirulina also possesses antioxidant and anti-inflammatory properties.

Source(s):
Microalgae Characterization for Consolidated and New Application in Human Food, Animal Feed and Nutraceuticals. Antonio Molino, Angela Iovine, Patrizia Casella, Sanjeet Mehariya, Simeone Chianese, Antonietta Cerbone, Juri Rimauro, and Dino Musmarra. Int J Environ Res Public Health. 2018 Nov; 15(11): 2436. Effects of Spirulina platensis microalgae on antioxidant and anti-inflammatory factors in diabetic rats. Fariba Nasirian, Masoumeh Dadkhah, Nasrollah Moradi-kor, and Zia Obeidavi. Diabetes Metab Syndr Obes. 2018; 11: 375–380

Product(s):
REVITALISING HERBAL TEA

Sulforaphane is a compound naturally occurring in plants belonging to the Cruciferae family, such as broccoli. A molecule possessing high antioxidant properties, strong enough to protect every cell from any sort of oxidative or inflammatory damage. Sulforaphane activates a large number of enzymes that play a role in cellular redox reactions and at a genetic level – regulates endogenous detoxification mechanisms. For this reason, it has been studied in numerous clinical cases. In pulmonary diseases, sulforaphane has been shown to increase the broncho-protective activities of other natural agents. In digestive diseases where there is a high degree of oxidative stress in the gastrointestinal mucosae, like infections caused by Helicobacter pylori or those caused by non-steroidal anti-inflammatories, sulforaphane has been shown, both in vitro and in vivo, to have good antibacterial activity. Thus effective against Helicobacter pylori, as well as playing a cytoprotective role in cases of drug-induced gastritis.

Source(s):
Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress Akinori Yanaka. Division of Gastroenterology, Hitachi Medical Education and Research Center, Faculty of Medicine, University of Tsukuba, 2-1-1, Jonan-cho, Hitachi-shi, Ibaraki-ken, 317-0077, Japan
Curr Pharm Des. 2017 Aug; 23(27): 4066–4075
Fahey, J. W., & Talalay, P. (1999). Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food Chem Toxicol, 37(9-10), 973-979
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways Robert H. Brown,Curt Reynolds, Allison Brooker, Paul Talalay, and Jed W. Fahey. Respir Res. 2015; 16(1): 106

Product(s):
DS2 / REFLUX HERBA
IS1 / ANTOXI PLUS
IS2 / ANTOXI PLUS FLUID
M1 / SINE ADIPEM
RS1 / SULFOSIN
RS3 / MIRABILUS VOX
RS4 / MIRABILUS PETTORALIS

t

Tolu balsam is a sap-like substance exuded when an incision is made in the bark of the South American tree, Myroxylon balsamum. The oleoresin obtained this way is defined as a balsam thanks to its dual properties. “Soothing” and skin protective in case of burns, insect bites and ulcers and “therapeutic” on the respiratory system in cases of dry or wet coughs. The essential oils it contains make this product an extremely effective expectorant and antispasmodic.

Source(s):
Assessment report on Myroxylon balsamum (L.) Harms var. pereirae (Royle) Harms, balsamum EMA/MPC/712648/2014

Product(s):
RS4 / MIRABILUS PETTORALIS

Thyme is a plant belonging to the Labiatae family. Its essential oil, obtained through the distillation of its leaves is rich in thymol and possesses numerous therapeutic properties. Used as an antibacterial against both gram-positive and gram-negative bacteria and as an antifungal. It also has spasmolytic and secretomotor activity – stimulating mucus production. It works as an antioxidant and anti-inflammatory, inhibiting the biosynthesis of prostaglandins, blocking the COX enzyme.

Source(s):
Assessment report on Thymus vulgaris L., Thymus zygis Loefl. ex. L. aetheroleum EMA/HMPC/131903/2009

Product(s):
RS5 / MIRABILUS PROFUNDUM

W

White willow is a plant belonging to the Salicaceae family, used since ancient times for its famous active constituent salicylic acid. Salicylic acid, found in the tree’s bark, is the precursor of acetylsalicylic acid – the active ingredient in aspirin. The dried bark extract has analgesic, anti-inflammatory, antineuralgic, antipyretic and antirheumatic properties. Ideally suited for reducing fever, relieving menstrual pain, alleviating headaches and hot flashes, and soothing general ailments linked to wet weather conditions. In fact, it has proven to be effective in treating pain and inflammation caused by rheumatism, arthritis and tendinitis.

Source(s):
Assessment report on Salix cortex. EMA/HMPC/80628/2016

Product(s):
MSS1 / ARNICA30
MSS2 / ARTUUM

          Group Company

NATURALSALUS

NATURALSALUS srl
Administrative offices: Via Firenze, 34 – 20069 Trezzano Rosa (MI)
Tel. 02 909313.220 – Fax 02 909313.211
E-mail: info@naturalsalus.it
PEC: naturalsalus.pec@legalmail.it
Registered office: Via Galvani, 39 – 39100 Bolzano
Capitale sociale int.vers. € 10.000,00
C.F.-P.IVA e Reg. Imprese MI 03167530215 – REA BZ – 237703

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