The Devil's Claw is a perennial plant of the Pedaliaceae family, used for the treatment of painful joint manifestations, rheumatism, arthrosis and arthritis, thanks to its analgesic and anti-inflammatory properties. The roots are rich in glucoiridoids: harpagoside and procumbide, which act like NSAIDs (non-steroidal anti-inflammatories) but without giving the same side effects on the stomach, inhibit the activity of the COX2 enzyme, preventing the cascade inflammatory.
Sources:
Assessment report on Harpagophytum procubens radix EMA/HMPC/627058/2015
The Spirea is a plant of the Rosaceae family, known for its anti-inflammatory and diuretic properties. The phytocomplex contains salicylic derivatives (salicylic aldehyde, methyl salicylate, ethyl salicylate), flavonoids, vitamin C, essential oils, and mineral salts. Considered along with willow, the "vegetable salicylate", the plant has anti-inflammatory, analgesic, and antipyretic effects, as it inhibits the synthesis of prostaglandins (PGE2), which are responsible for pain and the inflammatory process of tissues.
However, unlike synthetic anti-inflammatory drugs, it does not have an ulcerogenic action (gastritis, ulcer), as the presence of mucilage gives spirea a protective action for the mucous membranes, capable of reducing spasms and erosive processes of the gastric walls.
Sources:
Assessment report on Filipendula ulmaria flos. EMA/HMPC/434892/2010
The White willow is a plant of the Salicaceae family, known since ancient times for a famous active ingredient it contains: salicylic acid.
Salicylic acid is the precursor of acetylsalicylic acid, the active ingredient of aspirin, and is contained within the bark. The dry extract obtained from it has analgesic, anti-inflammatory, anti-neuralgic, antipyretic and anti-rheumatic properties. It is particularly suitable for relieving fever, pain caused by the menstrual cycle, for fighting headaches and hot flashes and, in general, for soothing ailments associated with excessive humidity. In fact, it has also been proven effective for the treatment of painful and inflammatory conditions such as rheumatic pain. arthritis and tendinitis.
Sources:
Assessment report on Salix cortex. EMA/HMPC/80628/2016
The Birch is a perennial plant of the Betulaceae family of great use in the phytotherapeutic field, both for the properties of the leaves and for the sap. The birch sap from which the bud extract is extracted, contains two heterosides capable of enzymatically releasing of methyl salicylate, a substance with analgesic and anti-inflammatory activity, methyl salicylate acts on the COX2 enzyme, an important enzyme in the inflammatory cascade, inhibiting its action, significantly reducing the painful component and eliminating stagnant fluids in the tissues joints.
Sources:
Assessment report on Betula pubescens. EMA/HMPC/573240/2014
The Ash tree is a plant of the Oleaceae family, with strong medicinal properties. The dry extract obtained from the leaves has diuretic, anti-inflammatory, antirheumatic, antiarthritic properties. This is due to the presence of coumarins (fraxin, fraxetine, frassinol, esculetin) and of flavonoids (quercetin, rutin, hydroxyframoside), which inhibit the production of endogenous inflammatory mediators such as prostaglandins.
Sources:
Assessment report on Fraxinus excelsior folium. EMA/HMPC/239269/2011
The product combats rheumatic and muscular pain
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